NFL Free Pick: Arizona vs. San Francisco Betting Lines & Preview

Cardinals vs 49ers Free Pick

NFL Week 17 Regular Season action sees the Arizona Cardinals taking on the San Francisco 49ers on Sunday, December 28 at Levi’s Stadium. Cappers Picks provides free *NFL*handicapping tips all season long.

The Jim Harbaugh era could come to a close in San Francisco on Sunday when the disappointing 49ers host the playoff bound Arizona Cardinals.

NFL Week 17 Betting Lines

Arizona (11-4) at San Francisco (7-8)
When: 4:25 PM ET, Sunday, December 28, 2014
Where: Levi’s Stadium, Santa Clara, California
Broadcast: FOX
Cardinals NFL Betting Odds: +6 -110
49ers NFL Betting Odds: -6 -110
NFL Over/Under Betting Odds: 36½ -110
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The Cards still have a chance to lock up the NFC West and a first round bye but will have to do so with a raw rookie at quarterback against a team that will likely be playing the game of their lives for their embattled coach.

So will the 49ers be able to send their Coach out in style of will San Francisco be just another improbable victim of Arizona’s incredible season?


The Arizona Cardinals will start their fourth different Quarterback on Sunday – fourth!

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Yup Rookie Logan Thomas will be under center after Ryan Lindley failed to impress last week against the Rams. Let’s face it – the Cards just need to get through this week and hope and pray that Drew Stanton is healthy enough to get himself into Arizona’s next game.

Thomas has thrown nine NFL passes and has completed just one so far – that came to Andre Ellington who himself is out for the season. If Thomas struggles however we will likely see Lindley back in the game – Lindley has yet to throw a TD pass in 225 NFL pass attempts! To make matters worse for the Cardinals offensively is the fact that either Stephan Taylor or Kerwynn Williams will be the starting running backs for the Cards – yikes!

Arizona’s strength – the defense was seriously exposed last week to the tune of 596 yards against.

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Expect another run-heavy attack against this week – the 49ers rumbled for 355 yards last week and will likely attack the Cards gave up boat loads of rushing yards to the Seahawks in a 35-6 drubbing last week.


It should be an emotional game for the San Francisco 49ers this week – if they can’t get up for their coach’s swan song, there is little hope. Along with Harbaugh, this could be the last game in a 49ers uniform for Frank Gore – you can bet every player on the 49ers roster will give their best to two guys that have made the franchise so successful.

Last week Colin Kaepernick got back to what has made him so successful – he ran for 151 yards in a loss to the Chargers while throwing for just 114 yards – a 90 yard TD run was arguably his highlight of the season. The offense resembled more of the one that has made them one of the most feared teams in the game the last few years – they were untouchable on the ground last week and the passing game was more of a decoy than a focal point.

Like the Cardinals there has to be some concern over the defense in San Francisco – one that was carved up last week against Philip Rivers and the boys.

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Ray MacDonald has been officially let go and the availability of Aldon Smith is seriously in question after he admitted to being with MacDonald around the time of the alleged sexual assault. The good news is that Arizona will likely pose little threat against the defense this week.

NFL Week 17 Betting Trends

• ARI are 13-3 ATS vs. a team with a losing record.
• ARI are 7-2 ATS in their last 9 games in December.
• ARI are 12-4 ATS in their last 16 vs. NFC.
• ARI are 3-9 ATS in their last 12 meetings.

The 49ers have won five straight games at home versus Arizona – expect more of the same this week. Emotion alone should carry the 49ers this week – there is no way they don’t lay everything on the line for their coach and their most trusted running back.

NFL Week 17 Betting Prediction:

Add in the fact that the Cards will start a raw rookie at QB and a couple of underwhelming running backs and this looks like an easy win for San Francisco. This has all the makings of a 20-6 game!

San Francisco 49ers -6

Check out our Updated NFL Week 17 Odds.

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By DaveB

Dave B has been a Fantasy Football writer for us for 10 years. A couch potato wannabe, Dave’s insights have been read by 10’s of people for years. He hope’s for world peace + global relaxation. Enjoy and remember only smoke things that are completely natural.